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Equisetin

CAT: 0931-T11219-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T11219-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
57749-43-6
Target
Others, STAT, AMPK, Reactive Oxygen Species, HIV Protease, Dehydrogenase, Antibiotic, Antibacterial
Related Pathways
Metabolism, Proteases/Proteasome, Chromatin/Epigenetic, NF-κB, Others, Stem Cells, Microbiology/Virology, PI3K/Akt/mTOR signaling, JAK/STAT signaling, Immunology/Inflammation
Bioactivity
Equisetin, an N-methylserine-derived acyl tetramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537, functions as a Quorum-sensing inhibitor (QSI) that specifically attenuates QS-regulated virulence phenotypes in P. aeruginosa, presenting a potent lead for treating P. aeruginosa infections without hindering bacterial growth. This tetramate-containing natural product possesses antibiotic and cytotoxic properties, effectively inhibiting the growth of Gram-positive bacteria and HIV-1 integrase activity, yet it does not impact Gram-negative bacteria.
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[H][C@@]12C[C@H](C)CC[C@@]1([H])[C@@](C)([C@H](\C=C\C)C=C2)C(\O)=C1\C(=O)[C@H](CO)N(C)C1=O
Molecular Formula
C22H31NO4
Molecular Weight
373.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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