Equisetin

• Target:

  Others|||STAT|||AMPK|||Reactive Oxygen Species|||HIV Protease|||Dehydrogenase|||Antibiotic|||Antibacterial

• Related Pathways:

  Metabolism|||Proteases/Proteasome|||Chromatin/Epigenetic|||NF-?B|||Others|||Stem Cells|||Microbiology/Virology|||PI3K/Akt/mTOR signaling|||JAK/STAT signaling|||Immunology/Inflammation

• Bioactivity:

  Equisetin, an N-methylserine-derived acyl tetramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537, functions as a Quorum-sensing inhibitor (QSI) that specifically attenuates QS-regulated virulence phenotypes in P. aeruginosa, presenting a potent lead for treating P. aeruginosa infections without hindering bacterial growth. This tetramate-containing natural product possesses antibiotic and cytotoxic properties, effectively inhibiting the growth of Gram-positive bacteria and HIV-1 integrase activity, yet it does not impact Gram-negative bacteria.

• Smiles:

  [H][C@@]12C[C@H](C)CC[C@@]1([H])[C@@](C)([C@H](\C=C\C)C=C2)C(\O)=C1\C(=O)[C@H](CO)N(C)C1=O

• Molecular Formula:

  C22H31NO4

• Molecular Weight:

  373.49

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  57749-43-6