DLK-IN-1

CAT: 0931-T11056-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T11056-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1620574-24-4

Target

MAPK, DNA Alkylation

Related Pathways

MAPK, DNA Damage/DNA Repair

Bioactivity

DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, retains excellent CNS permeability, and after multiple days of administration, its concentration exceeds the concentration required for DLK inhibition in the brain, so it has good tolerance Acceptability.

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[H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(OC(F)(F)F)c1)C1COC1

Molecular Formula

C20H24F3N5O2

Molecular Weight

423.43

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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VPC57424-01	DLK-IN-1
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A18676-10	DLK-IN-1 10mg
A18676-50	DLK-IN-1 50mg
A18676-5	DLK-IN-1 5mg
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