D-I03

• Target :

  DNA/RNA Synthesis

• Related Pathways :

  Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

• Purity :

  0.9965

• Bioactivity :

  D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. It specifically inhibits RAD52-dependent single-chain annealing (SSA) and D-loop formation, with IC50 values of 5 µM and 8 µM, respectively. D-I03 also inhibits the growth of BRCA1 and BRCA2 deficient cells and prevents the formation of damage-induced RAD52 foci, but does not affect RAD51 foci induced by Cisplatin.

• Smiles :

  CCN(CC)CCNC(=S)Nc1ccc2nc(cc(C)c2c1)N1CCN(CC)CC1

• Molecular Formula :

  C23H36N6S

• Molecular Weight :

  428.64

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  688342-78-1