D-I03

CAT: 0931-T10936-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T10936-01Size:1 mg
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CAS Number
688342-78-1
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Purity
0.9965
Bioactivity
D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. It specifically inhibits RAD52-dependent single-chain annealing (SSA) and D-loop formation, with IC50 values of 5 µM and 8 µM, respectively. D-I03 also inhibits the growth of BRCA1 and BRCA2 deficient cells and prevents the formation of damage-induced RAD52 foci, but does not affect RAD51 foci induced by Cisplatin.
Smiles
CCN(CC)CCNC(=S)Nc1ccc2nc(cc(C)c2c1)N1CCN(CC)CC1
Molecular Formula
C23H36N6S
Molecular Weight
428.64
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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