D-I03

• Target:

  DNA/RNA Synthesis

• Related Pathways:

  Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

• Purity:

  0.9965

• Bioactivity:

  D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. It specifically inhibits RAD52-dependent single-chain annealing (SSA) and D-loop formation, with IC50 values of 5 µM and 8 µM, respectively. D-I03 also inhibits the growth of BRCA1 and BRCA2 deficient cells and prevents the formation of damage-induced RAD52 foci, but does not affect RAD51 foci induced by Cisplatin.

• Smiles:

  CCN (CC) CCNC (=S) Nc1ccc2nc (cc (C) c2c1) N1CCN (CC) CC1

• Molecular Formula:

  C23H36N6S

• Molecular Weight:

  428.64

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  688342-78-1