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Cot inhibitor-1

CAT: 0931-T10865-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T10865-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
915365-57-0
Target
MAPK, TNF
Related Pathways
Apoptosis, MAPK
Purity
0.9919
Bioactivity
Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM) . Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a variety of cellular signaling pathways, particularly those involved in inflammation and immune responses. Cot inactivate-1 inhibits Cot activity and may have potential therapeutic effects on rheumatoid arthritis, inflammatory bowel disease and some types of cancer.
Smiles
Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cn(CCN5CCCCCC5)nn4)cc23)C#N)cc1Cl
Molecular Formula
C27H27Cl2FN8
Molecular Weight
553.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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