CNX-500

• Target:

  Others|||BTK

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Angiogenesis|||Others

• Bioactivity:

  CNX-500, a probe comprising a covalent Btk inhibitor chemically linked to biotin, exhibits significant inhibitory activity against Btk (IC50: 0.5 nM) and can form a covalent bond with Btk. Additionally, CNX-500 has low inhibitory effects on kinase EGFR and upstream Src-family kinases.

• Smiles:

  [H][C@]12CS[C@@H](CCCCC(=O)NCCCOCCOCCOCCCNC(=O)CCCC(=O)NCCCOc3cccc(Nc4ncc(C)c(Nc5cccc(NC(=O)C=C)c5)n4)c3)[C@@]1([H])NC(=O)N2

• Molecular Formula:

  C48H68N10O9S

• Molecular Weight:

  961.18

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1202758-21-1