CNX-500

CAT: 0931-T10854-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T10854-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1202758-21-1

Target

Others, BTK

Related Pathways

Tyrosine Kinase/Adaptors, Angiogenesis, Others

Bioactivity

CNX-500, a probe comprising a covalent Btk inhibitor chemically linked to biotin, exhibits significant inhibitory activity against Btk (IC50: 0.5 nM) and can form a covalent bond with Btk. Additionally, CNX-500 has low inhibitory effects on kinase EGFR and upstream Src-family kinases.

Smiles

[H][C@]12CS[C@@H](CCCCC(=O)NCCCOCCOCCOCCCNC(=O)CCCC(=O)NCCCOc3cccc(Nc4ncc(C)c(Nc5cccc(NC(=O)C=C)c5)n4)c3)[C@@]1([H])NC(=O)N2

Molecular Formula

C48H68N10O9S

Molecular Weight

961.18

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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