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CF53

CAT: 0931-T10773-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T10773-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1808160-52-2
Target
Epigenetic Reader Domain, Histone Acetyltransferase, CDK
Related Pathways
Chromatin/Epigenetic, Cell Cycle/Checkpoint
Purity
>99.99%
Bioactivity
CF53 is a highly potent, selective, and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM, and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, being very selective over non-BET bromodomain-containing proteins. CF53 exhibits potent anti-tumor activity both in vitro and in vivo.
Smiles
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(nn3C)C3CC3)c21
Molecular Formula
C24H25N7O2
Molecular Weight
443.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
BA4731-5.1CF53
A17175-100CF53 100mg
A17175-25CF53 25mg
A17175-5CF53 5mg
A17175-1CF53 1mg
A17175-50CF53 50mg
A17175-10CF53 10mg
M12767-01BET inhibitor CF53
A17175-10mM-DCF53 10mM * 1mL in DMSO

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