ATM Inhibitor-1

CAT: 0931-T10396-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T10396-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2135639-94-8

Target

ATM/ATR

Related Pathways

PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair

Bioactivity

ATM Inhibitor-1 is a highly potent, selective, and orally active ATM inhibitor (IC50: 0.7 nM) with anti-tumor activity. It exhibits weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50, 10.3 μM), PI3Kγ (IC50, 3 μM), and PI3Kδ (IC50, 0.73 μM) .

Smiles

N([C@@H](C)C1CCOCC1)C=2C3=C(N=NC2C(NC)=O)C=CC(=C3)C=4C=CC(OCCCN(C)C)=NC4

Molecular Formula

C27H36N6O3

Molecular Weight

492.61

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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