Aprocitentan D4

• Bioactivity:

  Aprocitentan D4 (ACT-132577 D4) is a deuterium-labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is a dual ETA/ETB antagonist (IC50s: 3.4 nM and 987 nM; pA2s: 6.7 and 5.5) .

• Smiles:

  O=S (N) (NC1=NC=NC (OC ([2H]) ([2H]) C ([2H]) ([2H]) OC2=NC=C (Br) C=N2) =C1C3=CC=C (Br) C=C3) =O

• Molecular Formula:

  C16H10D4Br2N6O4S

• Molecular Weight:

  550.22

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C