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Roflumilast

CAT: 0931-T1024-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T1024-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
162401-32-3
Target
PDE, RSV
Related Pathways
Metabolism, Microbiology/Virology
Purity
>99.99%
Bioactivity
Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activities. Upon administration, roflumilast and its active metabolite roflumilast N-oxide selectively and competitively bind to and inhibit PDE4, which leads to an increase of both intracellular levels of cyclic-3', 5'-adenosine monophosphate (cAMP) and cAMP-mediated signaling.
Smiles
O(CC1CC1)C2=C(OC(F)F)C=CC(C(NC=3C(Cl)=CN=CC3Cl)=O)=C2
Molecular Formula
C17H14Cl2F2N2O3
Molecular Weight
403.21
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
A4319-25Roflumilast

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