Roflumilast

• Target:

  PDE|||RSV

• Related Pathways:

  Metabolism|||Microbiology/Virology

• Purity:

  >99.99%

• Bioactivity:

  Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activities. Upon administration, roflumilast and its active metabolite roflumilast N-oxide selectively and competitively bind to and inhibit PDE4, which leads to an increase of both intracellular levels of cyclic-3', 5'-adenosine monophosphate (cAMP) and cAMP-mediated signaling.

• Smiles:

  O(CC1CC1)C2=C(OC(F)F)C=CC(C(NC=3C(Cl)=CN=CC3Cl)=O)=C2

• Molecular Formula:

  C17H14Cl2F2N2O3

• Molecular Weight:

  403.21

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  162401-32-3