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Propantheline bromide

CAT: 0931-T1006-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T1006-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
50-34-0
Target
AChR
Related Pathways
Neuroscience
Purity
≥98%
Bioactivity
Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propantheline Bromide is the bromide salt form of propantheline, a quaternary ammonium compound structurally related to belladonna alkaloids. An aspartic acid residue present in the N-terminal portion of the third transmembrane helix of the muscarinic receptor is believed to form an ionic bond with the tertiary or quaternary nitrogen of the antagonist. Antagonism leads to a reduction of exocrine glands secretions and to relax the bronchial muscle and reduce tone and motility of intestinal smooth muscle.
Smiles
[Br-].CC(C)[N+](C)(CCOC(=O)C1c2ccccc2Oc2ccccc12)C(C)C
Molecular Formula
C23H30BrNO3
Molecular Weight
448.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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