Busulfan

• Target :

  DNA Alkylation|||DNA Alkylator/Crosslinker|||Apoptosis

• Related Pathways :

  Apoptosis|||DNA Damage/DNA Repair

• Purity :

  0.9989

• Bioactivity :

  Busulfan is an alkylating antineoplastic agent derived from dimethane sulfonate, with cytotoxic and immunosuppressive properties. It primarily acts by forming carbonium ions in vivo, which induce cross-linking between DNA strands or between DNA and proteins, leading to DNA damage, inhibition of DNA replication, and suppression of RNA transcription. In addition, Busulfan can inhibit thioredoxin reductase and induce apoptosis. It is commonly used as a myeloablative agent in preconditioning regimens for bone marrow transplantation and can also be used to establish anemia models.

• Smiles :

  CS(=O)(=O)OCCCCOS(C)(=O)=O

• Molecular Formula :

  C6H14O6S2

• Molecular Weight :

  246.3

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  55-98-1