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Busulfan

CAT: 0931-T0923-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0931-T0923-01Size:500 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
55-98-1
Target
DNA Alkylation|||DNA Alkylator/Crosslinker|||Apoptosis
Related Pathways
Apoptosis|||DNA Damage/DNA Repair
Purity
0.9989
Bioactivity
Busulfan is an alkylating antineoplastic agent derived from dimethane sulfonate, with cytotoxic and immunosuppressive properties. It primarily acts by forming carbonium ions in vivo, which induce cross-linking between DNA strands or between DNA and proteins, leading to DNA damage, inhibition of DNA replication, and suppression of RNA transcription. In addition, Busulfan can inhibit thioredoxin reductase and induce apoptosis. It is commonly used as a myeloablative agent in preconditioning regimens for bone marrow transplantation and can also be used to establish anemia models.
Smiles
CS(=O)(=O)OCCCCOS(C)(=O)=O
Molecular Formula
C6H14O6S2
Molecular Weight
246.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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