Triamcinolone

CAT: 0931-MF-0003853-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0003853-01Size:500 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
124-94-7
Target
Interleukin|||Glucocorticoid Receptor|||COX
Related Pathways
Neuroscience|||Immunology/Inflammation|||Endocrinology/Hormones
Purity
0.996
Bioactivity
Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to translocation of the ligand-receptor complex to the nucleus and induces expression of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, pro-inflammatory cytokine production, including interleukin (IL) -1and IL-6, and the activation of cytotoxic T-lymphocytes is also inhibited. T-cells are prevented from making IL-2 and proliferating. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis through increasing Ikappa-B expression and curtailing activation of nuclear factor (NF) kappa-B.
Smiles
[H][C@@]12C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
Molecular Formula
C21H27FO6
Molecular Weight
394.43
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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