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Benzthiazide

CAT: 0931-T0782-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T0782-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
91-33-8
Target
Carbonic Anhydrase
Related Pathways
Metabolism
Purity
>99.99%
Bioactivity
Benzthiazide (Lemazide) is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics) . They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Smiles
NS(=O)(=O)c1cc2c(NC(CSCc3ccccc3)=NS2(=O)=O)cc1Cl
Molecular Formula
C15H14ClN3O4S3
Molecular Weight
431.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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