Erlotinib hydrochloride

CAT: 0931-T0373L-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0931-T0373L-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

183319-69-9

Target

Autophagy, EGFR

Related Pathways

Tyrosine Kinase/Adaptors, Autophagy, Angiogenesis, JAK/STAT signaling

Purity

0.9985

Bioactivity

Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM) . It is used for the treatment of non-small cell lung cancer.

Smiles

Cl.COCCOC1=C(OCCOC)C=C2C(NC3=CC(=CC=C3)C#C)=NC=NC2=C1

Molecular Formula

C22H23N3O4·HCl

Molecular Weight

429.9

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Erlotinib Hydrochloride

Erlotinib Hydrochloride is the hydrochloride salt of a quinazoline derivative with antineoplastic properties. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation.

CAS Number	183319-69-9
PubChem CID	176871
IUPAC Name	N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine;hydrochloride
Molecular Formula	C22H24ClN3O4
Molecular Weight	429.9
Topological Polar Surface Area	74.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	11
Heavy Atom Count	30
Formal Charge	0
Complexity	525

SMILES

COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl

InChI

InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H

InChIKey

GTTBEUCJPZQMDZ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 183319-69-9

CID: 176871

Formula: C22H24ClN3O4

MW: 429.9

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	429.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	11
Exact Mass	429.1455339
Monoisotopic Mass	429.1455339
Topological Polar Surface Area	74.7 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	525
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
A8234-5000	Erlotinib Hydrochloride
HY-12008-01	Erlotinib (Hydrochloride)
HY-12008S-01	Erlotinib-d6 (hydrochloride)
HY-12008S1	Erlotinib-13C6 (hydrochloride)
1588-1000	Erlotinib, Hydrochloride Salt
MBS8506454-01	Erlotinib Hydrochloride (Tarceva)
MBS5771910	Erlotinib-d6 hydrochloride
A10362-100	Erlotinib Hydrochloride 100mg
CS-O-00724	Erlotinib-13C6 Hydrochloride

Erlotinib hydrochloride

Chemical Information

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