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Colchicine

CAT: 0931-T0320-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T0320-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
64-86-8
Target
Autophagy, Apoptosis, Microtubule Associated
Related Pathways
Autophagy, Apoptosis, Cytoskeletal Signaling
Purity
0.9996
Bioactivity
Colchicine is an orally active natural alkaloid that acts by inhibiting microtubule polymerization (IC50 = 3 nM) and as a competitive antagonist of the α3 glycine receptor. It possesses broad anti-inflammatory, immunosuppressive, and antifibrotic activities, can inhibit NLRP3 inflammasome activation to prevent NSAID-induced small intestine injury, holds potential for gouty arthritis and rheumatoid arthritis research, and is commonly used to establish Alzheimer’s disease models.
Smiles
COC1=C(OC)C(OC)=C2C(CCC(NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1
Molecular Formula
C22H25NO6
Molecular Weight
399.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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