Clofarabine

CAT: 0931-T0297-08Size: 500 mgDry Ice: NoHazardous: No

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CAT#:0931-T0297-08Size:500 mg

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CAS Number

123318-82-1

Target

Apoptosis, Nucleoside Antimetabolite/Analog, Autophagy, DNA/RNA Synthesis

Related Pathways

Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Autophagy, Apoptosis

Purity

>99.99%

Bioactivity

Clofarabine (Clofarex) m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.

Smiles

Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F

Molecular Formula

C10H11ClFN5O3

Molecular Weight

303.68

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Clofarabine

Clofarabine is a purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia. It has a role as an antimetabolite and an antineoplastic agent. It is a member of adenosines and an organofluorine compound.

CAS Number	123318-82-1
PubChem CID	119182
IUPAC Name	(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
Molecular Formula	C10H11ClFN5O3
Molecular Weight	303.68
XLogP	0.9
Topological Polar Surface Area	119
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	2
Heavy Atom Count	20
Formal Charge	0
Complexity	370

SMILES

C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)Cl)N

InChI

InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1

InChIKey

WDDPHFBMKLOVOX-AYQXTPAHSA-N

Chemical Structure

2D Structure

CAS: 123318-82-1

CID: 119182

Formula: C10H11ClFN5O3

MW: 303.68

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	303.68
XLogP3	0.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	2
Exact Mass	303.0534451
Monoisotopic Mass	303.0534451
Topological Polar Surface Area	119 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	370
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
A1412-5.1	Clofarabine
469352-01	α-Clofarabine

Clofarabine

Chemical Information

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