Velnacrine

• Description :

  Velnacrine (HP 029 free base) is an inhibitor for acetylcholinesterase (AChE), with an IC50 of 3.27 μM. Velnacrine reverses the Scopolamine (HY-N0296) -induced amnesia in rat models, and exhibits acute toxicity with LD50 of 65 mg/kg[1].

• Product Name Alternative :

  HP 029 (free base) ; Hydroxytacrine

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H335

• Target :

  Cholinesterase (ChE)

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/velnacrine.html

• Purity :

  98.60

• Smiles :

  OC1CCCC2=NC3=CC=CC=C3C(N)=C21

• Molecular Formula :

  C13H14N2O

• Molecular Weight :

  214.26

• Precautions :

  P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

• References & Citations :

  [1]Tabarrini O, et al., Velnacrine thiaanalogues as potential agents for treating Alzheimer's disease. Bioorg Med Chem. 2001 Nov;9 (11) :2921-8.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• Isoform :

  AChE

• CAS Number :

  [124027-47-0]