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NKY80

CAT: 0804-HY-103195-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103195-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues[1][2].
CAS Number
299442-43-6
UNSPSC
12352005
Hazard Statement
H302
Target
Adenylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nky80.html
Purity
99.76
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1C2=CN=C(N)N=C2CC(C3=CC=CO3)C1
Molecular Formula
C12H11N3O2
Molecular Weight
229.24
Precautions
H302
References & Citations
[1]Onda T, et al. Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibitionof adenylyl cyclase isoforms. Biol Chem. 2001 Dec 21;276 (51) :47785-93.|[2]Harney JA, et al. Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: involvement of PI3K but not cAMP. Am J Physiol Endocrinol Metab. 2008 Jul;295 (1) :E155-61.|[3]Ortiz-Capisano MC, et al. Adenylyl cyclase isoform v mediates renin release from juxtaglomerular cells. Hypertension. 2007 Mar;49 (3) :618-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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