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SRPIN803

CAT: 0804-HY-114653-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114653-01Size:5 mg
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Description
SRPIN803 is a potent CK2 and SRPK1 dual inhibitor, with IC50s of 203 nM and 2.4 μM, respectively. SRPIN803 exhibits antiangiogenic activity. SRPIN803 can be used for the research of age-related macular degeneration[1][2][3].
CAS Number
380572-02-1
Product Name Alternative
1-O-hexyl-2,3,5-trimethylhydroquinone; HX-1171; BTT-105, Guanosine 5'-[β,γ-imido]triphosphate (trisodium)
UNSPSC
12352005
Target
Casein Kinase; SRPK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/srpin803.html
Concentration
10mM
Purity
99.17
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(N=C1SC(C(F)(F)F)=NN1C/2=N)C2=C/C3=CC=C(C(OC)=C3)O
Molecular Formula
C14H9F3N4O3S
Molecular Weight
370.31
References & Citations
[1]Leonidis G, et, al. Synthesis and Biological Evaluation of a c (RGDyK) Peptide Conjugate of SRPIN803. ACS Omega. 2021 Oct 14;6 (42) :28379-28393.|[2]Vedove AD, et, al. A novel class of selective CK2 inhibitors targeting its open hinge conformation. Eur J Med Chem. 2020 Jun 1;195:112267.|[3]Morooka S, et, al. Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK2

Alternative Products

CatalogName
BA3743-5SRPIN803

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