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ST91

CAT: 0804-HY-103203-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-103203-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ST91 is a α2-adrenoceptor (α2AR) agonist. ST91 activates both α2AAR and non-α2AAR subtypes to produce spinal antinociception[1][2][3].
CAS Number
4749-61-5
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/st91.html
Purity
99.75
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CCC1=C(NC2=NCCN2)C(CC)=CC=C1.[H]Cl
Molecular Formula
C13H20ClN3
Molecular Weight
253.77
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Graham BA, et, al. Synergistic interactions between two alpha (2) -adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. Pain. 2000 Mar;85 (1-2) :135-43. |[2]Maccari S, et, al. α-Adrenoceptor stimulation attenuates melanoma growth in mice. Br J Pharmacol. 2022 Apr;179 (7) :1371-1383. |[3]Stone LS, et, al. ST91 [2- (2,6-diethylphenylamino) -2-imidazoline hydrochloride]-mediated spinal antinociception and synergy with opioids persists in the absence of functional alpha-2A- or alpha-2C-adrenergic receptors. J Pharmacol Exp Ther. 2007 Dec;323 (3) :899-906.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor

Chemical Information

1H-Imidazol-2-amine, N-(2,6-diethylphenyl)-4,5-dihydro-, hydrochloride (1:1)
CAS Number4749-61-5
PubChem CID185944
IUPAC NameN-(2,6-diethylphenyl)-4,5-dihydro-1H-imidazol-2-amine;hydrochloride
Molecular FormulaC13H20ClN3
Molecular Weight253.77
Topological Polar Surface Area36.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count1
Rotatable Bond Count4
Heavy Atom Count17
Formal Charge0
Complexity238
SMILES
CCC1=C(C(=CC=C1)CC)NC2=NCCN2.Cl
InChI
InChI=1S/C13H19N3.ClH/c1-3-10-6-5-7-11(4-2)12(10)16-13-14-8-9-15-13;/h5-7H,3-4,8-9H2,1-2H3,(H2,14,15,16);1H
InChIKey
ZLRWFGBEDNTMEU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1H-Imidazol-2-amine, N-(2,6-diethylphenyl)-4,5-dihydro-, hydrochloride (1:1)
CAS: 4749-61-5
CID: 185944
Formula: C13H20ClN3
MW: 253.77
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight253.77
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count1
Rotatable Bond Count4
Exact Mass253.1345753
Monoisotopic Mass253.1345753
Topological Polar Surface Area36.4 Ų
Heavy Atom Count17
Formal Charge0
Complexity238
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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