FBXL11 (KDM2A, JHDM1A) FLAG-Avi-tag Recombinant

• Description:

  FBXL11 (KDM2A, JHDM1A) FLAG-Avi-tag Recombinant_x000D_ Catalog number: B2019115_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 10 µg_x000D_ Molecular Weight or Concentration: 82 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: ˆ’80°C_x000D_ Keywords: F-Box Protein 11, KDM2A, Ndy2, JHDM1A, FBL7, CXXC-type zinc finger protein 8, CXXC8, F-box and leucine-rich repeat protein 11, FBL11, FBXL11, F-box protein LILINA, KIAA1004, F-box/LRR-repeat protein 11, JmjC domain-containing histone demethylation protein_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Xu WH, Liang DY, Wang Q, Shen J, Liu QH, Peng YB. Knockdown of KDM2A inhibits proliferation associated with TGF-β expression in HEK293T cell Mol Cell Biochem. 2019 Jun;456(1-2):95-104._x000D_ 2: Liu X, Li J, Wang Z, Meng J, Wang A, Zhao X, Xu Q, Cai Z, Hu Z. KDM2A Targets PFKFB3 for Ubiquitylation to Inhibit the Proliferation and Angiogenesis of Multiple Myeloma Cells Front Oncol. 2021 May 17;11:653788._x000D_ 3: Tanaka Y, Okamoto K, Teye K, Umata T, Yamagiwa N, Suto Y, Zhang Y, Tsuneoka M. JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation EMBO J. 2010 May 5;29(9):1510-22._x000D_ 4: Wagner KW, Alam H, Dhar SS, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani AS, Chan CH, Erez B, Saigal B, Chung J, Lin HK, Wu X, Hung MC, Heymach JV, Lee MG. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling J Clin Invest. 2013 Dec;123(12):5231-46._x000D_ 5: Rizwani W, Schaal C, Kunigal S, Coppola D, Chellappan S. Mammalian lysine histone demethylase KDM2A regulates E2F1-mediated gene transcription in breast cancer cells PLoS One. 2014 Jul 16;9(7):e100888._x000D_ 6: Nilsson EM, Laursen KB, Whitchurch J, McWilliam A, Ødum N, Persson JL, Heery DM, Gudas LJ, Mongan NP. MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators Oncotarget. 2015 Nov 3;6(34):35710-25._x000D_ 7: Dhar SS, Alam H, Li N, Wagner KW, Chung J, Ahn YW, Lee MG. Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells J Biol Chem. 2014 Mar 14;289(11):7483-96._x000D_ 8: Lu DH, Yang J, Gao LK, Min J, Tang JM, Hu M, Li Y, Li ST, Chen J, Hong L. Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial€‘mesenchymal transition Oncol Rep. 2019 Feb;41(2):917-927._x000D_ 9: Pfau R, Tzatsos A, Kampranis SC, Serebrennikova OB, Bear SE, Tsichlis PN. Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1907-12._x000D_ 10: Rezazadeh S, Yang D, Biashad SA, Firsanov D, Takasugi M, Gilbert M, Tombline G, Bhanu NV, Garcia BA, Seluanov A, Gorbunova V. SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair Aging (Albany NY). 2020 Jun 25;12(12):11165-11184. _x000D_ _x000D_ Products Related to FBXL11 (KDM2A, JHDM1A) FLAG-Avi-tag Recombinant can be found at Proteins

• Short Description:

  Catalog Number: B2019115 (10 µg)_x000D_ FBXL11, also known as KDM2A or JHDM1A, is a histone demethylase that targets trimethylated lysine 36 on histone H3. It regulates gene expression and chromatin remodeling. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3