Products for Research Use Only
RegisterLogin

CYP3cide

CAT: 0804-HY-18642-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-18642-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CYP3cide (PF-4981517) is a potent, selective and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4) . The IC50 values for Midazolam 1’-hydroxylase activity are 0.03 μM, 17 μM, and 71 μM for CYP3A4, CYP3A5, and CYP3A7, respectively. CYP3cide can be used to distinguish the contributions of CYP3A4 versus CYP3A5 on agent metabolism[1].
CAS Number
1390637-82-7
Product Name Alternative
PF-4981517
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/cyp3cide.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=CC=C(C2=C(C3=NN(C)C4=NC=NC(N5C[C@@H](N6CCCCC6)CC5)=C43)C=NN2C)C=C1
Molecular Formula
C26H32N8
Molecular Weight
456.59
References & Citations
[1]Robert L Walsky, et al. Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs. Drug Metab Dispos. 2012 Sep;40 (9) :1686-97.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP3

Related Products

CatalogName
HY-163804Cyprocide-B

Alternative Products

CatalogName
RG-A261925-01Cyp3Cide
007427CYP3cide discontinued
A12544-2CYP3cide (PF 4981517) 2mg
A12544-100CYP3cide (PF 4981517) 100mg
A12544-50CYP3cide (PF 4981517) 50mg
A12544-25CYP3cide (PF 4981517) 25mg
A12544-10CYP3cide (PF 4981517) 10mg
A12544-5CYP3cide (PF 4981517) 5mg
A12544-10mM-DCYP3cide (PF 4981517) 10mM * 1mL in DMSO

Popular Products