Cisplatin

• Description:

  Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy[1][2][3].

• Product Name Alternative:

  Cis-Platinum; CDDP; cis-Diaminodichloroplatinum

• UNSPSC:

  12352300

• Hazard Statement:

  H300, H315, H317, H319, H334, H335, H350

• Target:

  Autophagy; DNA Alkylator/Crosslinker; Ferroptosis; Lipoxygenase; Pyroptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Cisplatin.html

• Purity:

  99.95

• Solubility:

  DMF : 10 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : ≥ 300 mg/mL|H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  Cl[Pt] (Cl) ([NH3]) [NH3]

• Molecular Formula:

  Cl2H6N2Pt

• Molecular Weight:

  300.05

• Precautions:

  H300, H315, H317, H319, H334, H335, H350

• References & Citations:

  [1]Wang X, et al. Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem. 2000 Dec 15;275 (50) :39435-43.|[2]Cummings BS, et al. Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways. J Pharmacol Exp Ther. 2002 Jul;302 (1) :8-17.|[3]Park HR, et al. Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice. BMC Cancer. 2009 Mar 17;9:85.|[4]Shimeda Y, et al. Protective effects of capsaicin against cisplatin-induced nephrotoxicity in rats. Biol Pharm Bull. 2005 Sep;28 (9) :1635-8.|[5]Hall MD, et al. Say no to DMSO: dimethylsulfoxide inactivates cisplatin, NSC 241240, and other platinum complexes. Cancer Res. 2014 Jul 15;74 (14) :3913-22.|[6]Wu K, et al. Cisplatin inhibits the progression of bladder cancer by selectively depleting G-MDSCs: A novel chemoimmunomodulating strategy. Clin Immunol. 2018 Aug;193:60-69.|[7]Noha Alassaf, et al. Autophagy and necroptosis in cisplatin-induced acute kidney injury: Recent advances regarding their role and therapeutic potential. Front Pharmacol. 2023 Jan 30:14:1103062. |[8]Ryan M Williams, et al. Kidney-Targeted Redox Scavenger Therapy Prevents Cisplatin-Induced Acute Kidney Injury. Front Pharmacol. 2022 Jan 3:12:790913.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  15663-27-1