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Dihydrorotenone

CAT: 0804-HY-N4202-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N4202-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dihydrorotenone is an insecticide and irreversible inhibitor of mitochondrial complex I and can cross the blood-brain barrier. Dihydrorotenone may induce Parkinson's disease. Dihydrorotenone induces apoptosis in human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. The oral LD50 of dihydrorotenone in rats is approximately 2.5 g/kg. Dihydrorotenone exhibits insecticide activity and cytotoxicity to plasma cells. Dihydrorotenone can be used to establish animal models of Parkinson's disease, safety assessment of natural pesticides, and potential cancer chemoprevention studies[1][2][3][4].
CAS Number
6659-45-6
UNSPSC
12352005
Hazard Statement
H370
Target
Apoptosis; Insecticide; p38 MAPK
Type
Natural Products
Related Pathways
Apoptosis; MAPK/ERK Pathway; Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dihydrorotenone.html
Purity
99.66
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1[C@]2([H])[C@](COC3=CC(OC)=C(OC)C=C32)([H])OC4=C5C(O[C@@H](C(C)C)C5)=CC=C14
Molecular Formula
C23H24O6
Molecular Weight
396.43
Precautions
H370
References & Citations
[1]Zhang J, et al. The natural pesticide dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway. PLoS One. 2013 Jul 26;8 (7) :e69911.|[2]Caboni P, et al. Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease. Chem Res Toxicol. 2004 Nov;17 (11) :1540-8.|[3]AMBROSE AM, et al. Toxicological and pharmacological studies on dihydrorotenone. J Am Pharm Assoc Am Pharm Assoc. 1953 Jun;42 (6) :364-6.|[4]Kim K J, et al. Inhibitory Effects of 1', 2'-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo. 해부· 생물인류학, 2011, 24 (3) : 165-174.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
MBS5760319Dihydrorotenone
TRE00381',2'-Dihydrorotenone

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