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A20 Antibody / TNFAIP3

CAT: 0013-GTR18575154Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18575154Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. High A20 expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade) . These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.
UniProt
P21580
Reactivity
Human
Immunogen
A portion of amino acids 241-356 from the human protein was used as the immunogen for the A20 antibody.
Clonality
Monoclonal
Clone
TNFAIP3/2813
Conjugation
Unconjugated
Field of Research
Cell Biology
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the A20 antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2c, kappa

UniProtKB · P21580

Tumor necrosis factor alpha-induced protein 3

TNAP3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P21580
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNFAIP3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TNF alpha-induced protein 3
EC number
2.3.2.-, 3.4.19.12
Processing
—
Secondary accessions
B2R767, E1P588, Q2HIX9, Q5VXQ7, Q9NSR6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Biological process

ApoptosisInflammatory responseUbl conjugation pathway

Cellular component

CytoplasmLysosomeNucleus

Disease

Disease variant

Molecular function

DNA-bindingHydrolaseMultifunctional enzymeProteaseThiol proteaseTransferase

Ligand

Metal-bindingZinc

Domain

RepeatZinc-finger

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