Products for Research Use Only
RegisterLogin

SREBP1 Antibody

CAT: 0013-GTR18574972Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR18574972Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1) . When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.
UniProt
P36956
Reactivity
Human
Immunogen
A recombinant full-length human protein was used as the immunogen for this SREBP1 antibody.
Clonality
Monoclonal
Clone
SREBP1/1578
Conjugation
Unconjugated
Field of Research
Metabolism Research
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the SREBP1 antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2b, kappa

UniProtKB · P36956

Sterol regulatory element-binding protein 1

SRBP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P36956
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SREBF1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SREBP-1
EC number
—
Processing
—
Secondary accessions
B0I4X3, B0I4X4, D3DXC4, Q16062, Q59F52, Q6P4R7, Q6PFW7, Q6PJ36, Q8TAK9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Biological process

Cholesterol metabolismLipid metabolismSteroid metabolismSterol metabolismTranscriptionTranscription regulation

Cellular component

Cytoplasmic vesicleEndoplasmic reticulumGolgi apparatusMembraneNucleus

Disease

Disease variantIchthyosis

PTM

PhosphoproteinUbl conjugation

Domain

TransmembraneTransmembrane helix

Related Products

CatalogName
GTR18684112-01SREBF1/SREBP1 Rabbit Polyclonal Antibody
GTR18771565-01SREBF1 | SREBP1 Recombinant Rabbit mAb
GTR18300600-01SREBP1 polyclonal antibody
GTR18233296-01SREBP1 polyclonal antibody
GTR18900699-01SREBP1 peptide
GTR18920643SREBP1 (SREBF1) Human Over-expression Lysate
GTR18940995SREBP1 (SREBF1) Human Over-expression Lysate
GTR18944585SREBP1 (SREBF1) Human Over-expression Lysate
GTR18924344SREBP1 (SREBF1) Human Over-expression Lysate
GTR18104413-01SREBP1 Rabbit Polyclonal Antibody

Alternative Products

CatalogName
70R-34580SREBP1 antibody
NBP3-07878-20ugMouse Monoclonal SREBP1 Antibody (SREBP1/1578)
NBP3-08432BMouse Monoclonal SREBP1 Antibody (SREBP1/1578) [Biotin]
NBP3-08432HMouse Monoclonal SREBP1 Antibody (SREBP1/1578) [HRP]
NBP3-08432PCPMouse Monoclonal SREBP1 Antibody (SREBP1/1578) [PerCP]
NBP3-08432APCMouse Monoclonal SREBP1 Antibody (SREBP1/1578) [Allophycocyanin]
36-3212-100Anti-SREBP1 Monoclonal Antibody (Clone: SREBP1/1578)
NBP3-08432PEMouse Monoclonal SREBP1 Antibody (SREBP1/1578) [PE]
NBP3-08432FMouse Monoclonal SREBP1 Antibody (SREBP1/1578) [FITC]
70R-34579SREBP1 antibody (Ser439)

Popular Products