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COX2 Antibody / PTGS2

CAT: 0013-GTR18574925Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18574925Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA) . Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS) . Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.
UniProt
P35354
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 442-572) was used as the immunogen for the COX2 antibody.
Clonality
Monoclonal
Clone
COX2/1941
Conjugation
Unconjugated
Field of Research
Cancer Biology; Metabolism Research
Purification
Protein G affinity chromatography
Dilution
ELISA (order BSA-free format for coating), Western blot: 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the COX2 antibody should be determined by the researcher.
Tested Applications
ELISA, WB
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2b, kappa

UniProtKB · P35354

Prostaglandin G/H synthase 2

PGH2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35354
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTGS2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.14.99.1
Processing
Precursor
Secondary accessions
A8K802, Q16876
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlycoproteinS-nitrosylation

Molecular function

DioxygenaseOxidoreductasePeroxidase

Cellular component

Endoplasmic reticulumMembraneMicrosomeNucleus

Biological process

Fatty acid biosynthesisFatty acid metabolismLipid biosynthesisLipid metabolismProstaglandin biosynthesisProstaglandin metabolism

Ligand

HemeIronMetal-binding

Domain

Signal

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