Moesin Antibody

CAT: 0013-GTR18575426Size: 7 mLDry Ice: NoHazardous: No

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CAT#:0013-GTR18575426Size:7 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Recognizes 78kDa moesin protein. Moesin, a member of the Talin-4.1 superfamily, is a linking protein of the submembraneous actin cytoskeleton. It is expressed in variable amounts in cells of different phenotypes such as macrophages, lymphocytes, fibroblastic, endothelial, epithelial, and neuronal cell lines but not in blood cells. The ERM proteins, ezrin, radixin, and moesin are involved in a variety of cellular functions, such as cell adhesion, migration, and the organization of cell surface structures, and are highly homologous, both in protein sequence and in functional activity, with merlin/schwannomin, a neurofibromatosis-2-associated tumor-suppressor protein. Cell lines of epithelial and mesothelial origin contain both moesin and radixin whereas cells of endothelial and lymphoid origin express moesin.

UniProt

P26038

Reactivity

Human

Immunogen

Recombinant human protein was used as the immunogen for this Moesin antibody.

Clonality

Monoclonal

Clone

SPM562

Conjugation

Unconjugated

Purification

Protein G affinity chromatography

Dilution

The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

The optimal dilution of the Moesin antibody for each application should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Tested Applications

IHC-P

Host or Source

Mouse

Preservative

Prediluted in 1X PBS, 0.1 mg/ml rAlbumin, 0.05% sodium azide; For IHC use only

Isotype

Mouse IgG1, kappa

UniProtKB · P26038

Moesin

MOES_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P26038
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: MSN
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: —

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinS-nitrosylation

Cellular component

Cell membraneCell projectionCytoplasmCytoskeletonMembrane

Disease

Disease variant

Biological process

Host-virus interaction

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Alternative Products

Catalog	Name
abx141676-01	Moesin (Moesin) Antibody
10R-10353	Moesin antibody