Recombinant PAX8 Antibody

CAT: 0013-GTR18575254Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18575254Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.

UniProt

Q06710

Reactivity

Human

Immunogen

A synthetic peptide corresponding to the C-terminus of the human protein was used as the immunogen for the recombinant PAX8 antibody.

Clonality

Recombinant

Clone

PAX8/3688R

Conjugation

Unconjugated

Field of Research

Stem Cell & Developmental Biology

Purification

Protein A affinity chromatography

Dilution

Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the recombinant PAX8 antibody should be determined by the researcher.

Tested Applications

IHC-P

Host or Source

Rabbit

Preservative

1 mg/ml in 1X PBS; rAlbumin free, sodium azide free

Isotype

Rabbit IgG

UniProtKB · Q06710

Paired box protein Pax-8

PAX8_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q06710
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PAX8
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q09155, Q16337, Q16338, Q16339, Q4ZG35, Q96J49

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Congenital hypothyroidismDisease variant

Molecular function

Developmental proteinDNA-binding

Biological process

DifferentiationTranscriptionTranscription regulation

Cellular component

Nucleus

Domain

Paired box

PTM

Phosphoprotein

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