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Telatinib (mesylate)

CAT: 0804-HY-10527C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10527C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Telatinib mesylate (Bay 57-9352 mesylate) is a potent and orally active VEGFR2, VEGFR3, PDGFα, and c-Kit inhibitor with IC50s of 6 nM, 4 nM, 15 nM and 1 nM, respectively[1].
CAS Number
332013-26-0
Product Name Alternative
Bay 57-9352 (mesylate)
UNSPSC
12352005
Target
C-Kit; PDGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/telatinib-mesylate.html
Purity
99.74
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=NC=CC(COC2=NN=C(NC3=CC=C(Cl)C=C3)C4=C2OC=C4)=C1)NC.OS(=O)(C)=O
Molecular Formula
C21H20ClN5O6S
Molecular Weight
505.93
References & Citations
[1]Steeghs N, et al.Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor.Clin Cancer Res. 2008 Jun 1;14 (11) :3470-6.|[2][2] Sodani K, et al. Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo. Biochem Pharmacol. 2014 May 1;89 (1) :52-61.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PDGFRα; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4

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