B3GNT6, soluble fragment, Human Recombinant
CAT:
26-P1221-5
Size:
5 µg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

B3GNT6, soluble fragment, Human Recombinant
- Description: β1,3Nacetylglucosaminyltransferase 6 (β3GnT6) transfers N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to N-acetylgalactosamine (GalNAc). β3GnT6 is also known as the core 3 synthase, because it creates the core 3 oligosaccharide structure in the mucin-type O-glycan, GlcNAcβ13GalNAcα1serine/threonine. Core 3 synthase is a type II transmembrane protein, and is localized to stomach, small intestine and colonic tissues. It has long been known that synthesis of the core 3 structure is down-regulated in colonic cancer cells and it has been shown that the expression of β3GnT6 is also down-regulated. Colonic cancer cells transfected with β3GnT6 have reduced metastatic potential compared to non-transfected cells, and when injected into mice show decreased tumor formation. Pancreatic cancer cells transfected with β3GnT6 show a similar phenotype, which has been attributed to the addition of core3 O-glycans to α2β1 integrin.
- CAS Number: 9000-83-3
- Shipping Conditions: Gel Pack
- Storage Conditions: -20°C
- Shelf Life: 12 months