Human CellExp™CD4, human recombinant

CAT: 0026-7834-100Size: 100 µgDry Ice: NoHazardous: No
CAT#:0026-7834-100Size:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Cluster of Differentiation 4 (CD4), also known as T-cell surface antigen T4/Leu-3 (LEU-3) and CD4mut, is a single-pass type I membrane glycoprotein, and is a member of the immunoglobulin superfamily. CD4 expressed on the surface of T helper cells, monocytes, macrophages, and dendritic cells. It has four immunoglobulin domains (D1 to D4) that are exposed on the extracellular surface of the cell: D1 and D3 resemble immunoglobulin variable (IgV) domains. D2 and D4 resemble immunoglobulin constant (IgC) domains. CD4 is a co-receptor that assists the T cell receptor (TCR) with an antigen-presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR by recruiting an enzyme, known as the tyrosine kinase lck, which is essential for activating many molecules involved in the signaling cascade of an activated T cell. CD4 also interacts directly with MHC class II molecules on the surface of the antigen-presenting cell using its extracellular domain. The extracellular domain adopts an immunoglobulin-like beta-sandwich with seven strands in 2 beta sheets, in a Greek key topology. CD4 has also been shown to interact with SPG21, Lck and Protein unc-119 homolog. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
CAS Number
9000-83-3
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
12 months

Related Products

CatalogName
P1015-25Human CellExp™ CD45, human recombinant
P1495-10Human CellExp™ CD46, Human Recombinant
7385-10Human CellExp™ CD47, human recombinant
P1015-10Human CellExp™ CD45, human recombinant
P1214-50Human CellExp™ CD40, Mouse Recombinant
P1077-10Human CellExp™ CD47, rabbit recombinant
P1076-50Human CellExp™ CD47, rat recombinant
P1077-50Human CellExp™ CD47, rabbit recombinant
P1214-250Human CellExp™ CD40, Mouse Recombinant
P1076-10Human CellExp™ CD47, rat recombinant

Alternative Products

CatalogName
MBS7614367-01Recombinant Human CD4
TP727720CD4 Human Recombinant Protein
MBS8304941-01Recombinant Human CD4 Protein
MBS141778-01Recombinant Human CD4, Active
PROTP01730-5-250ugHuman recombinant CD4 protein
7-01456Recombinant Human Soluble CD4
MBS553128-01Human Soluble CD4 Recombinant
PPT-11559Human CD4 Recombinant Protein

Popular Products