Lck, Active

CAT: 0026-7733-5Size: 5 µgDry Ice: YesHazardous: No
CAT#:0026-7733-5Size:5 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Lck (p56lck) is a member of the src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene. Lck behaves as a proto-oncogene and can lead to cell transformation upon activation. A number of human cancer cell lines show overexpression of Lck, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers. Colon cancers and T-cell leukemias frequently show defective regulation of Lck expression and activity.Inappropriate T cell activation and proliferation have been identified as an early event in auto-immune disease. Lck plays a prominent role in T-cell development, activation, proliferation and survival. Lck is coupled to both the CD4 and CD8 antigens (which serve as receptors for nonpolymorphic regions of products of the major histocompatibility complex and have been implicated in the regulation of T-cell growth) in T-cells and phosphorylates CD3. Lck phosphorylates many cellular protein substrates as a result of T-cell receptor signaling cascade. This includes phosphorylation of proteins such as Ras GTPase-activating protein (RasGAP) and two RasGAP-associated proteins, p56(dok) and p62(dok).
Shipping Conditions
dry ice
Storage Conditions
-80°C
Shelf Life
12 months

Related Products

CatalogName
3498-30TLck Antibody
3498-100Lck Antibody
3499-100Phospho-Lck Antibody
3498BP-50Lck Blocking Peptide
A1027-100Phospho-LCK (Tyr394) Monoclonal Antibody
7751-5STK3, Active
7757-5JNK1, Active
7771-5MET, Active
7755-5MAPKAPK3, Active
7736-5CAMK1G, Active

Alternative Products

CatalogName
MBS517158-01LCK, Active
B2022287Lck Protein, Active
3704-KS-010Recombinant Human Active Lck CF
GWB-CBBFF1LCK, Active Human Recombinant Protein
IHULCKARNGST50UGLCK Active Recombinant Protein N-GST Tag
MBS635660-01Lck, active, Recombinant, Human (Lymphocyte-specific Tyrosine Kinase)
L1565-06CLck, p56lck, active, Recombinant, Human (Lymphocyte-specific Tyrosine Kinase)
219999LCK, Active, Recombinant, Human (Lymphocyte-specific Tyrosine Kinase) discontinued
B2019016Recombinant Human Lck Protein (Full Length, GST Tag, Active)
L1565-17CLck, active, Recombinant, Human, GST-Tag (Lymphocyte-specific Tyrosine Kinase)

Popular Products