Ilginatinib

CAT: 0804-HY-19631A-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-19631A-01Size:1 mg

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Description

Ilginatinib (NS-018) is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM) .

CAS Number

1239358-86-1

Product Name Alternative

NS-018

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NS-018.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1N=CC(C2=CC(N[C@H](C3=CC=C(F)C=C3)C)=NC(NC4=NC=CN=C4)=C2)=C1

Molecular Formula

C21H20FN7

Molecular Weight

389.43

References & Citations

[1]Nakaya Y, et al. Efficacy of NS-018, a potent and selective JAK2/Src inhibitor, in primary cells and mouse models of myeloproliferative neoplasms. Blood Cancer J. 2011 Jul;1 (7) :e29.|[2]Kuroda J, et al. NS-018, a selective JAK2 inhibitor, preferentially inhibits CFU-GM colony formation by bone marrow mononuclear cells from high-risk myelodysplastic syndrome patients. Leuk Res. 2014 May;38 (5) :619-24.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

JAK1; JAK2; JAK3; Tyk2

Alternative Products

Catalog	Name
PZB35886-01	Ilginatinib
PZB35885-01	Ilginatinib hydrochloride
BUP12491-01	Ilginatinib maleate
A16224-200	Ilginatinib (NS-018) 200mg
A16224-1	Ilginatinib (NS-018) 1mg
A16224-100	Ilginatinib (NS-018) 100mg
A16224-50	Ilginatinib (NS-018) 50mg

Ilginatinib

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