Human Recombinant PIN1 | Gentaur

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

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P1434-01	Recombinant Human PIN1
P1434-03	Recombinant Human PIN1
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MBS7614060-04	Recombinant Human PIN1
MBS7614060-03	Recombinant Human PIN1
MBS566068-01	Pin1 (human), (recombinant)

Human Recombinant PIN1

CAT:

26-6304-100

Size:

100 µg

Price:

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For price, please contact [email protected].

Human Recombinant PIN1

Description: Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA ,PLK I, Wee, and Myt1 kinases), several transcription factors like β-Catenin, c-Jun, and the tumor suppressor protein p53 , and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1.
Shipping Conditions: gel pack
Storage Conditions: -20°C
Shelf Life: 12 months

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