Leptin Receptor, human recombinant

CAT:

26-4582-50

Size:

50 µg

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Description: Leptin receptor (LEPR), also known as OB-R and B219, is a single transmembrane-domain receptor of the cytokine receptor family. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is expressed at high levels in hematopoietic stem cells, lymphohematopoietic cell lines, as well as adult reproductive organs. Several isoforms of LEPR have been identified, and LEPR structurally contains two hemopoietin receptor domains, a fibronectin type III domain and a WSXWS domain within the extracellular region. Interaction of leptin and leptin receptor is crucial for bodyweight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.
CAS Number: 9000-83-3
Shipping Conditions: gel pack
Storage Conditions: -20°C
Shelf Life: 12 months

Cat	Name
4582-1000	Leptin Receptor, human recombinant
4582-50	Leptin Receptor, human recombinant
4582-10	Leptin Receptor, human recombinant
5582-100	Leptin Receptor Antibody
4366-02	Leptin, human recombinant
4366-5	Leptin, human recombinant
4366-1	Leptin, human recombinant
4366-10	Leptin, human recombinant
E4653-100	Leptin (Human) ELISA Kit
K4777-100	Leptin (human) ELISA Kit

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