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Ranirestat

CAT: 0804-HY-15314-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15314-01Size:5 mg
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Description
Ranirestat (AS-3201) potent and orally active aldose reductase (AR) inhibitor with IC50s of 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively, and a Ki of 0.38 nM for recombinant human AR. Ranirestat has the potential for diabetic sensorimotor polyneuropathy treatment. Ranirestat also has a neuroprotective effect on diabetic retinas[1][2].
CAS Number
147254-64-6
Product Name Alternative
AS-3201
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Ranirestat.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(N1CC2=CC=C(Br)C=C2F)C3=CC=CN3[C@]4(C(NC(C4)=O)=O)C1=O
Molecular Formula
C17H11BrFN3O4
Molecular Weight
420.19
Precautions
H315, H319, H335
References & Citations
[1]Matsumoto T, et al. Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux. J Pharmacol Sci. 2009 Feb;109 (2) :203-10.|[2]Toyoda F, et al. Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats. J Diabetes Res. 2014;2014:672590.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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