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EI1

CAT: 0026-B2270-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-B2270-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EI1 is a potent EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC₅₀s = 15 and 13 nM, respectively). It displays 90-fold selectivity for EZH2 over EZH1 and >10,000-fold selectivity over other lysine methyltransferases. EI1 blocks cellular H3K27 methylation and activates PRC2-specific gene expression. Inhibition of EZH2 by EI1 in diffused large B cell lymphoma cells carrying Y641 mutations results in decreased proliferation, cell cycle arrest, and apoptosis.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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