Products for Research Use Only
RegisterLogin

4-Octyl itaconate

CAT: 0026-B2171-50Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0026-B2171-50Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
4-Octyl itaconate is an endogenous metabolite of itaconate that activates the anti-inflammatory transcription factor Nrf2 (also known as NFE2L2) by lipopolysaccharide in mouse and human macrophages. Itaconate alkylates cysteine residues 151, 257, 288, 273 and 297 on the protein KEAP1, enabling Nrf2 to increase the expression of downstream gene. In vivo, 4-octyl itaconate (50 mg/kg) decreases serum levels of IL-1β and TNF-α, increases Nrf2 protein expression, and protects against LPS-induced lethality in wild-type, but not Nrf2 knockout, mice.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

Related Products

CatalogName
1782-100GOctyl-β-D-thioglucopyranoside
1782-50GOctyl-β-D-thioglucopyranoside
1782-5GOctyl-β-D-thioglucopyranoside
1782-1GOctyl-β-D-thioglucopyranoside
1646-100Gn-Octyl-β-D-glucopyranoside
1646-50Gn-Octyl-β-D-glucopyranoside
1646-25Gn-Octyl-β-D-glucopyranoside
1646-5Gn-Octyl-β-D-glucopyranoside
E4645-1004-Hydroxynonenal (4-HNE) ELISA Kit
B2495-254μ8C

Alternative Products

CatalogName
MBS3844184-014-Octyl Itaconate
TRC-O293977-2.5MG4-Octyl Itaconate-13C5

Popular Products