TEPP-46

CAT: 0026-B2164-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-B2164-5Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TEPP-46 (ML-265) is a potent and selective PKM2 activator. TEPP-46 activates tumor-specific PKM2 (EC₅₀ = 92 nM) by binding to the dimer-dimer interface between two subunits of PKM2 and inducing tetramerization, which is the most active form of the enzyme. In mice with A549 xenograft tumors, ML-265 displays good oral bioavailability with relatively low clearance, long half-life.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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