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CBL0137

CAT: 0026-B2036-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-B2036-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CBL0137 is a metabolically stable curaxin that activates p53 (EC₅₀ = 0.37 μM) and inhibits NF-κB (EC₅₀ = 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates efficacy of gemcitabine (Cat. No.1759 in preclinical models of pancreatic cancer.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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