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FPS-ZM1

CAT: 0026-B1933-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-B1933-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FPS-ZM1 is a high-affinity, brain-permeable, RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo. In a rat model of intracerebral hemorrhage, FPS-ZM1 attenuates blood-brain barrier and white matter fiber damage. It ameliorates inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

Alternative Products

CatalogName
C3723-10FPS-ZM1

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