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FRAX597

CAT: 0026-B1890-1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0026-B1890-1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FRAX597 is a potent group I PAK (p21-activated kinase) inhibitor (IC₅₀ values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). Displays significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC₅₀ >10 μM for PAK4). FRAX597 inhibits the proliferation of NF2-deficient schwannoma cells in culture and displays potent anti-tumor activity in vivo.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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