Curcubitacin E

CAT: 0026-B1592-1Size: 1 mgDry Ice: NoHazardous: No
CAT#:0026-B1592-1Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Curcubitacin E is a potent actin depolymerization inhibitor. Shown to have a different mechanism of action compared to Jasplakinolide (Cat. No. 1689), binding to a different site. Binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, stabilizing F-actin without affecting actin polymerization or nucleation. Does not bind to monomeric actin (G-actin). Acts as an immunomodulator with anti-inflammatory and anti-tumorigenic properties in a range of cancer cell lines, mediated by its action on the cellular cytoskeleton, on mitotic pathways as well as on cellular autophagy.
Shipping Conditions
Gel Pack
Storage Conditions
-20°C
Shelf Life
36 months

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