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Mithramycin A

CAT: 0026-B1532-1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0026-B1532-1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mithramycin A is a DNA-binding, anti-tumor and neuroprotective antibiotic used as a chemotherapeutic agent. It mediates its protective function, in part, by regulating acetylation of histones or transcription factors and, thereby, chromatin accessibility to transcriptional machinery. As a selective Sp1 inhibitor, mithramycin A binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, which inhibits their expression. Mithramycin A (at 10-200 nM) can sensitize tumor cells to TRAIL-induced apoptosis and has been used to selectively target tumor cells in many different cancer models.
Shipping Conditions
Gel Pack
Storage Conditions
-20°C
Shelf Life
36 months

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M2300-01Mithramycin
MBS3841071-01Mithramycin A

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