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VR23

CAT: 0026-B1515-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-B1515-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VR23 is a potent and selective inhibitor of trypsin-like proteasomes (IC₅₀ = 1 nmol/L), chymotrypsin-like proteasomes (IC₅₀ = 50-100 nmol/L), and caspase-like proteasomes (IC₅₀ = 3 μmol/L). The main molecular target of VR23 was β2 of the 20S proteasome catalytic subunit. It also deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells.
Shipping Conditions
Gel Pack
Storage Conditions
-20°C
Shelf Life
36 months

Alternative Products

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B6026-5VR23
A13650-50VR23 50mg
A13650-25VR23 25mg
HY-W720448VR23-d8
A13650-5VR23 5mg
A13650-200VR23 200mg
A13650-100VR23 100mg
A13650-10VR23 10mg
GW0993-5mgVR23 [Proteasome Inhibitor]
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