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AT-13148

CAT: 0026-B1144-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-B1144-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AT13148 is a potent, ATP-competitive multi-AGC kinase inhibitor that displays antitumor activity. AT13148 blocks AKT, p70S6K, PKA, ROCK, and SGK substrate phosphorylation inducing concentration dependent apoptosis in cancer cells. It also shows anti-tumor efficacy in HER2-positive, PIK3CA-mutant BT474 breast, PTEN-deficient PC3 human prostate cancer and PTEN deficient MES-SA uterine tumor in xenografts. Gene expression studies shows that AT13148 has a predominant effect on apoptosis genes.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

Alternative Products

CatalogName
MBS130289-01AT-13148
FA137648-01AT 13148

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