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AG-221 (Enasidenib)

CAT: 0026-B1070-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-B1070-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AG-221(Enasidenib) is a potent, selective, and reversible inhibitor of mutant IDH2 (isocitrate dehydrogenase type 2). It specifically inhibits IDH2 in the mitochondria, blocking the formation of oncometabolite 2-hydroxyglutarate (2HG). In in vitro studies, AG-221 reduces 2-HG levels by >90%, reverses histone and DNA hypermethylation, and induces cellular differentiation in leukemia cell models.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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