EXP-3174

CAT: 0026-9672-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-9672-5Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EXP-3174 is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. EXP-3174 is a potent angiotensin II receptor, type 1 (AT1) antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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