GSK-4112

CAT: 0026-9663-5Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0026-9663-5Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

GSK-4112 is a selective agonist for REV-ERBα (EC₅₀ = 0.4 μM). At 10 μM, GSK-4112 can reset the circadian rhythm in a phasic manner by inhibiting expression of the circadian target gene bmal1 and reduce glucose output by 30% in mouse primary hepatocytes by repressing the expression of several gluconeogenic genes. GSK-4112 is useful as a chemical tool to probe the function of REV-ERbα in transcriptional repression, regulation of circadian biology, and metabolic pathways.

Shipping Conditions

gel pack

Storage Conditions

-20°C

Shelf Life

36 months

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B7460-5	GSK 4112
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GSK-4112

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